Evaluation of Anti Hyperglycemic Studies on Hypericum hookerianum in Streptozotocin(STZ) and Nicotinamide Induced Diabetic Rats

The aim of this study was investigate antihyperglycemic effect of ethyl acetate extracts of leaves and stem of Hypericum hookerianum (HH) as in streptozotocin and nicotinamide induced diabetic rats. Male Wistar rats were administrated with leaf (HHL) and stem(HHS) extracts (200 mg/kg)of Hypericum hookerianum orally for 28days and blood glucose was measured once in week about 4weeks.The HHL extract showed more reduction in blood glucose leavel by 49 % on the 4the week of treatment when compared to controlled STZ group. At the end of the study significant reduction in lipid profile such as Triglycerides, HDL, Total Cholesterol, along with urea, uric acid and creatinine were found to be reduced in treated group. The experimental data revealed that the HHL extract posses significant antihyperglycemic effects than HHS extracts.